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- W2353986729 abstract "Objective To establish a minipig models of no-reflow after percutaneous coronary intervention of acute myocardial infarction(AMI).Methods A total of 26 Wuzhishan minipigs were chosen.Left ventriculography and coronary angiography(CAG)were performed sequentially by femoral approach.AMI with no-reflow was set up by dilating balloon to occlude the coronary artery and reperfusion after the injection of microthrombi into the left anterior descending artery.At the same time,left ventricular hemodynamic parameters were recorded.Changes in electrocardiogram(ECG)and intracoronary ECG(IC-ECG)were monitored.Results 21 animals survived after the procedure and 19 of them reached the criteria of AMI with no-reflow(TIMI≤2,CTFC≥36.2).The success rate of model establishment was 73.1%.The hemodynamic parameters includeing heart rate,LVEDP,and PCWP were increased,but blood pressure decreased at the time when no-reflow was formed,compared with those before the LAD was occluded.During the experiment,the changes in ECG and IC-ECG were similar to those observed in human AMI.Conclusion Minipig is an ideal species for the establishment of animal no-reflow model after reperfusion,microthrombus injection and balloon occlusion of LAD." @default.
- W2353986729 created "2016-06-24" @default.
- W2353986729 creator A5033119716 @default.
- W2353986729 date "2008-01-01" @default.
- W2353986729 modified "2023-09-25" @default.
- W2353986729 title "Establishment of a Minipig Model of No-Reflow after Percutaneous Coronary Intervention for Acute Myocardial Infarction" @default.
- W2353986729 hasPublicationYear "2008" @default.
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