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- W2353996886 abstract "Objectives:To establish a method for the determination conacentration of fluconazole in human plasma by HPLC and apply it to the pharmacokinetic study of fluconazole.Methods:Fluconazole in plasma was extracted with Bond elut solid phase extraction,HPLC instrument was adopted with C_(18)reversed-phase column(4.6 mm× 150 mm,5 μm)and monitored by UV.The mobile phase composed of 0.01 mol·L~(-1)KH_2PO_4(1000 mL 0.01 mol ·L~(-1)KH_2PO_4 with 200 μL triethylamine)-acetonitrile-methanol(60:24:16),eluated with a flow rate of 1.0 mL·min~(-1),detection wavelength was 267 nm with phenacetin as internal standard.Results:The calibration curve of fluconazole was in the range of 0.1-9.6 μg·mL~(-1)(r=0.9997).The detection limit was 0.1 μg·mL~(-1)(S/N 4).The recoveries of methodology were 93.7%-102.1% with intra-day RSD and inter-day RSD were less than 6%.Conclusions:The method has good sensitivity,precision and simple.It is shown to be suitable for pharma- cokinetic studies of fluconazole,in human and the clinical monitoring of the plasma concentration of fluconazole." @default.
- W2353996886 created "2016-06-24" @default.
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- W2353996886 date "2008-01-01" @default.
- W2353996886 modified "2023-09-23" @default.
- W2353996886 title "RP-HPLC determination of fluconazole concentrations in human plasma and its application" @default.
- W2353996886 hasPublicationYear "2008" @default.
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