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- W2353999994 abstract "Objectives To investigate the effects of subcutaneous administration of insulin on diabetes in NOD mice,and to explore the mechanism of immune tolerance induced by insulin. Methods Sixty female NOD mice were randomly divided into insulin group(n=32)and PBS group(n=28).Insulin-treated mice were injected subcutaneously with Humulin N 6U+IFA 60μl at 4,12,20,28 weeks of age respectively,while PBS group received PBS 60μ1+IFA 60μl.Insulitis and β cell apoptosis of islets were observed,and IL-4 and IFN-γ in sera and supernatants of spleen cells were measured.IL-4 and IFN-γ mRNA were measured by RT-PCR.Adoptive transfer tests were conducted to examine diabetes incidence. Results Insulin group versus PBS group showed the lower levels of the diabetes incidence(28.6% vs 85.7%,P0.05) and apoptotic β cell rate[(1.2±0.4)% vs (6.8±1.4)%,P0.05]and higher IL-4 levels of sera and spleen-cell supernatants,while IFN-γ levels were lower(all P0.05).IFN-γ mRNA levels in islets and spleen cells were lower and IL-4 mRNA levels were higher in insulin group than those in PBS group(all P0.05). Adoptive transfer of diabetes study showed that the diabetes incidence in insulin group was lower than that in PBS group (41.7% vs 80%,P0.05). Conclusion Subcutaneous administration of insulin may induce the regulatory T cells, and make Th1 to Th2 cytokine shifts in the system and islets, thus preventing the β-cell apoptosis and the diabetes." @default.
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- W2353999994 date "2007-01-01" @default.
- W2353999994 modified "2023-09-26" @default.
- W2353999994 title "Subcutaneous administration of insulin preventing diabetes is correlated with regulatory T cells and Th cytokine shift in NOD mice" @default.
- W2353999994 hasPublicationYear "2007" @default.
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