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- W2354000696 abstract "OBJECTIVE: To explore the expressions of SPARC MMP-2 and VEGF in colorectal cancer tissues,and analyze the relationship and the clinical significance.METHODS: Universal two-step method was used to examine the expressions of SPARC,MMP-2 and VEGF in 60 cases colorectal cancer specimens.RESULTS: The expression of SPARC in tumor cells was lower than that in stromal cells(χ2=14.545,P=0.000).Survival analysis results showed that the level of SPARC's expression was related to patients' prognosis.Both progression free survival(PFS) and over survival(OS) in lower expression group were shorter than those in higher expression group(P=0.000).Adversely,patients had shorter PFS(P=0.024)and OS(P=0.022)in higher expression MMP-2,and shorter PFS in higher expression of VEGF(P=0.029) while the OS had no significant(P=0.139).CONCLUSIONS: Low level expression of SPARC may promote the invasion and metastasis of colorectal cancer and the mechanism is related to increased expression of MMP-2 and VEGF,which leads to degradation of matrix,damage of basement membrane and formation of new blood vessels.To explore the expression of SPARC,MMP-2 and VEGF may forecast patients' prognosis." @default.
- W2354000696 created "2016-06-24" @default.
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- W2354000696 date "2012-01-01" @default.
- W2354000696 modified "2023-09-26" @default.
- W2354000696 title "Relationship and clinical significance of SPARC,MMP-2 and VEGF protein expression in colorectal cancer tissues" @default.
- W2354000696 hasPublicationYear "2012" @default.
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