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- W2354014730 abstract "Objective To analyze the correlation of the HBV-DNA loads in serum and breast milk in HBV carrier mothers and provide a scientific basis for safety breast-feeding. Methods The hepatitis B virus marker(HBV-M)and HBV-DNA loads in the serum of HBV carrier mothers were detected by ELISA and FQ-PCR respectively. The correlation between the two variables was analyzed. Results The HBV-DNA in the breast milk lower than 500 copies/ml was thought to be negative. The negative rates of the HBV-DNA in the breast milk of Group A(with positive HBsAg, HBeAg and anti-HBc), Group B(with positive HBsAg and anti-HBc or positive HBsAg and HBeAg)and Group C(with positive HBsAg, anti-HBe and antiHBc)were 11.7%(15/128), 72.3%(11/15)and 94.9%(185/195), respectively, which were statistically significant(P 0.05). The HBV-DNA was simultaneously detected in the serum and breast milk of 248 HBV carrier mothers. The positive rates of HBV-DNA in the serum and breast milk in Group A were 95.4%(83/87)and 80.7%(71/87)respectively, showing significant difference(P 0.05).The rates in Group B were 46.2%(6/13)and 30.8%(4/13),without statistical difference(P 0.05). The rates in Group C were 31.8%(37/148)and 4.1%(6/148), indicating significant difference(P 0.05). The two variables were positively and highly correlated for each group. Conclusions The HBV-DNA loads in the serum and breast milk are different among HBV carrier mothers with different infection modes. The loads should be determined in HBV carrier mothers in time in order to guide the safe breast-feeding." @default.
- W2354014730 created "2016-06-24" @default.
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- W2354014730 date "2014-01-01" @default.
- W2354014730 modified "2023-09-26" @default.
- W2354014730 title "Exploration of the correlation of the HBV-DNA loads in serum and breast milk in HBV carrier mothers" @default.
- W2354014730 hasPublicationYear "2014" @default.
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