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- W2354014787 abstract "Objective To investigate the changes in the morphology and the time course of activated microglias in rats with brain injury. Methods The craniocerebral injury model was established by Feeney et al method. Twenty-one SD rats were randomly divided into control group (n=3) and traumatic group (n=18), which was divided into 6 subgroups according to the time when the animals were sacrificed after the craniocerebral injury. Immunohistochemical SABC method was used to determine the expression of OX-42 in the injured brain tissues. Results In the control group, the microglias of brain tissues kept quiescent condition, OX-42 staining was negative or light, and the cells features were unclear or could not be observed. The microglias manifested light response, and OX-42 was light stained, OX-42 cells were found but their feature were unclear 1 hour after the injury. The response of microglias was obvious, OX-42 staining manifested anachromasis 6 hours after the injury. The response of microglias peaked, the cells features were clear, and the spines on the cellular processes were clearly found 12 hours after the injury. The response of microglias decreased, and OX-42 was light stained again 24, 48 and 72 hours after the injury. The early microglia response was also observed in the hippocampal CA1 area after the injury. Conclusions The microglias in the injured brain tissues begin to be activated 1 hour after the injury. The response of microglias in the injured brain tissues becomes significant 6 hours after the injury, peaks 12 hours after the injury and tapers ever since." @default.
- W2354014787 created "2016-06-24" @default.
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- W2354014787 date "2006-01-01" @default.
- W2354014787 modified "2023-09-26" @default.
- W2354014787 title "Changes in Morphology and Time Course of Activated Microglias in Rats with Brain Injury" @default.
- W2354014787 hasPublicationYear "2006" @default.
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