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- W2354035379 abstract "Aim To explore the reverse of 2,6-Diisopropylphenol,ginsenoside Rg-1,lithium against the impairment of learning-memory and the hyperphosphorylation of protein Tau induced by electroconvulsive shock and the concentration of glutamic acid in the hippocampus in depressed rats,in order to compare the therapeutic effects and mechanisms of three medicines.Methods As the analysis of variance of factorial design set up two intervention factors which were the electroconvulsive shock groups(two levels: no disposition;A course of electroconvulsive shock) and the drug intervention groups(four levels: Microinjection of 2,6-Diisopropylphenol,ginsenoside Rg-1,lithium and Saline).Sixty-four adult depression model rats whose olfactory bulbs were removed were randomly divided into eight experimental groups(n = 8,in each group).The Morris water maze test was started in order to evaluate learning-memory.The content of glutamate in the hippocampus of rats was detected by High Performance Liquid Chromatography.The content of protein Tau which includes Tau-5 and p-AT8 Ser202 in the hippocampus of rats was detected by Western blot.Results 2,6-Diisopropylphenol,ginsenoside Rg-1 and lithium protected against the impairment of learning-memory induced by electroconvulsive shock in depressed rats.The 2,6-Diisopropylphenol and ginsenoside Rg-1 reduced the content of glutamate.These three medicines reduced the hyperphosphorylation of protein Tau in the hippocampus of depressed rats.Conclusions 2,6-Diisopropylphenol,ginsenoside Rg-1 and lithium can protect against the impairment of learning-memory induced by electroconvulsive shock in depressed rats though reducing the hyperphosphorylation of protein Tau.The first two are not content with the glutamate in the hippocampus." @default.
- W2354035379 created "2016-06-24" @default.
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- W2354035379 date "2012-01-01" @default.
- W2354035379 modified "2023-09-25" @default.
- W2354035379 title "2,6-Diisopropylphenol,ginsenoside Rg-1 and lithium protects against the impairment of learning-memory induced by electroconvulsive shock in depressed rats" @default.
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