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- W2354038989 abstract "Objective To investigate the role of CD4+CD25+Foxp3+regulatory T cells in the immunopathogenesis of condyloma acuminatum(CA) and to study the relationship between these cells and HPV subtypes. Methods The counts of CD4+CD25+Foxp3+regulatory T cells in peripheral blood in 30 patients with CA and 30normal controls were detected by flow cytometry. HPV subtypes were detected by human papillomavirus genotyping kit in 30 patients with CA. Results The percentage of CD4+CD25+Foxp3+regulatory T cells in peripheral blood in patients with CA was higher than that in the healthy controls(P 0. 05). Among the CA patients,the percentage of CD4+CD25+Foxp3+regulatory T cells in the relapsed CA group was higher than that in the first onset CA group(P 0. 01); Patients with long duration of CA exhibited higher percentage of CD4+CD25+Foxp3+regulatory T cells than patients with short duration(P 0. 01). However,the percentage of CD4+CD25+Foxp3+regulatory T cells was similar in the CA with high-risk and low-risk HPV subtypes(P 0. 05). Conclusion The increase in CD4+CD25+Foxp3+regulatory T cells in patients with CA may be related to cell-mediated immunodeficiency,but not to HPV subtypes." @default.
- W2354038989 created "2016-06-24" @default.
- W2354038989 creator A5051075205 @default.
- W2354038989 date "2014-01-01" @default.
- W2354038989 modified "2023-09-23" @default.
- W2354038989 title "Detection of CD4~+ CD25~+ Foxp3~+ Regulatory T cells in the Peripheral Blood of Patients with Condyloma Acuminatum and its Correlation with HPV Subtypes" @default.
- W2354038989 hasPublicationYear "2014" @default.
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