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- W2354080585 abstract "Objective To investigate the expressions of CK5,CK8 and P63 protein and to explore their relations with clinicopathologic characteristics of breast cancer.Methods CK5,CK8 and P63 protein were detected in 96 cases of breast invasive ductal carcinoma by SP immunohistochemical technique.Results The expression of CK5 was weak in breast invasive ductal carcinoma,and only 17 cases(17.7%) were positive expression.The expression of CK8 was high in breast invasive ductal carcinoma and 89 cases(92.7%) were positive.Seventy-seven cases(80.2%) showed CK5-/CK8+ phenotype,5 cases(5.2%) were CK5+/CK8-phenotype,and 12 cases(12.5%) were CK5+/CK8+ phenotype,only 2 cases(2.1%) were CK5-/CK8-phenotype.These phenotypes were correlated with patients' age,tumor grade,lymph node metastasis and clinical stage.The expression of P63 in breast invasive ductal carcinoma was weak and 8 cases(8.3%) showed rare neoplastic cells positive staining.Conclusion CK5+/CK8+,CK5+/CK8-or P63+ phenotype breast cancer is highly malignant,prognosis is worse,and the phenotype might be novel molecular marker to predicate the progression of breast cancer." @default.
- W2354080585 created "2016-06-24" @default.
- W2354080585 creator A5061541496 @default.
- W2354080585 date "2008-01-01" @default.
- W2354080585 modified "2023-09-23" @default.
- W2354080585 title "Expressions of CK5,CK8 and P63 Protein and Their Clinical Significance in Breast Invasive Ductal Carcinoma" @default.
- W2354080585 hasPublicationYear "2008" @default.
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