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- W2354082014 abstract "Objective To observe the inhibitive effects on tongue cancer by union treated with HSV-TK and IL-2 and to discuss its mechanism.Methods Animal models of nude mice loaded on Tca8113 tongue cancer were set up.Transference of HSV-TK and IL-2 gene in vivo was done on transplanted tumors.The experiments involved 20 nude mice,divided into four groups A,B,C,D of 5 mice each.Group A was used as the control,and injected by normal saline;group B was used as the virus vector control,and injected by the virus vector 5×108PFU;group C was the experimental group,and injected by TK 5×108PFU;group D was another experimental group,and injected by TK(5×108PF)+IL-2(5×108PFU).After 48h,GCV abdominal injection was given to nude mice of group B,C,D,100mg/kg/daily,twice every day,for 10 days.The following day after the last medicine was given,all nude mice were sacrificed.The transplanted tumors were measured and observed by light microscope and transmission electron microscope(TEM).Results The weights of the transplanted tumor of group A,B,C,D were 1.52±0.49g,1.44±0.42g,0.91±0.24g,0.36±0.24g,respectively.The ratio of tumor inhibition was 40% of group C and 76% of group D.The weighs of transplanted tumor were smaller in group C and group D than that in group A and group B(P0.01).There were significantly difference between any two groups(P0.01),exception group A and group B.The results of light microscope in TK group revealed small apoptotic region and shrunk cells.There were not only many apoptotic cells in TK+IL-2 group,but also extinct tumor cells.The results of TEM in TK and TK+IL-2 group revealed many apoptotic cells with their cytoplasm shrinkage,the chromatin condensed into block,and dispersed unevenly.A volume of apoptotic bodies were formed.Conclusion HSV-TK/GCV and IL-2 could suppress the growth of Tca8113 transplanted tumors.The effect of HSV-TK+IL-2 on Tca8113 transplanted tumors was much better than that of HSV-TK alone." @default.
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- W2354082014 date "2008-01-01" @default.
- W2354082014 modified "2023-09-24" @default.
- W2354082014 title "Inhibitive effect of HSV-TK and IL-2 on transplanted tumor of human tongue cancer" @default.
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