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- W2354103659 abstract "Objective To investigate the effect of aging on resting state human brain activity in visual cortex by using functional magnetic resonance imaging technique(fMRI).Methods Ten healthy old and ten healthy young volunteers participated in our block design fMRI experiments.Subjects were instructed to listen carefully and make silently the valence of the words(abstract or concrete)during task conditions.In rest condition,subjects were told lying quietly with eyes closed.Data were analyzed with SPM 2 software.We used reverse subtracting method to obtain the group averaged deactivation map and make further analysis with mask function.Results Our data revealed nearly the same deactivated brain pattern between the old and young group,which nearly overlapping with the default mode networks.These brain regions included posterior cingulate and precuneous cortex(BA 7),medial prefrontal cortex(BA 32/10),bilateral dorsal prefrontal gyrus(BA 9),bilateral inferior parietal cortex(BA 39/40),bilateral visual cortex(BA 18、19) and insula(BA 13).With further analysis,we found significantly great magnitude of deactivation in visual cortex of old subjects than that in young subjects.Conclusion Our findings supported the default mode network hypothesis and revealed that the old subjects might have great neural activity in visual cortex than young subjects during rest state." @default.
- W2354103659 created "2016-06-24" @default.
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- W2354103659 date "2007-01-01" @default.
- W2354103659 modified "2023-09-23" @default.
- W2354103659 title "Health aging modulation of the resting state human brain activity in visual cortex" @default.
- W2354103659 hasPublicationYear "2007" @default.
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