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- W2354103698 abstract "Objective To explore the kidney protecting effect and possible mechanism under which the renal tissues in 5 /6 nephrectomy rats was intervened by emodin-polylactic-co-glycolic acid nanoparticles.Methods Rats were randomly divided into two groups,eight as sham-operated group and twenty-four as model group.Twenty-four rats in model group were randomly and equally assigned into model group(model group),emodin group eight(EMD)and nanoparticles group eihgt(NPs).Drugs were given to rats in different groups for a total 8 weeks,then 24 h urine protein,blood urea nitrogen(BUN) and creatinine(SCr) were measured;kidney pathological changes were observed under optical microscope;protein and mRNA expression of growth factor beta-1(TGF-β1) as well as connective tissue growth factor(CTGF) in renal tissues were detected respectively by RT-PCR methods and immunohistochemistry.Results After treated with drugs,compared with sham group,24 h urine protein,blood urea nitrogen,serum creatinine,mRNA and protein expression of TGF-β1 and CTGF of rats in model group were both increased(P0.01).Compared with model group,24 h urine protein,blood urea nitrogen,serum creatinine,mRNA and protein expression of TGF-β1 and CTGF of rats in EMD group and NPs group were both decreased(P0.01);Compared with EMD group,24 h urine protein,blood urea nitrogen,serum creatinine,mRNA and protein expression of TGF-β1 and CTGF of rats in NPs group were both decreased(P0.01).Conclusions EMD-PLGA NPs inhibits renal fibrosis and slows down the progress of chronic kidney disease." @default.
- W2354103698 created "2016-06-24" @default.
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- W2354103698 date "2014-01-01" @default.
- W2354103698 modified "2023-09-24" @default.
- W2354103698 title "Emodin-polylactic-co-glycolic acid NPs delays chronic renal failure by 5/6 nephrectomy" @default.
- W2354103698 hasPublicationYear "2014" @default.
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