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- W2354108947 abstract "Adrenomedulin (AdM) is a newly isolated peptide with hypotensive activity in normotensive rats. The cardio protective action of human AdM (13～52), a C terminal fragment of AdM (1～52),was observed on the myocardial injury model produced by subcutaneous injection of isoproterenol (69 μmol·kg -1 ) into rats. Treatment with human AdM (13～52) (10 nmol·kg -1 ·d -1 , iv.) significantly ameliorated isoproterenol induced myocardial necrosis inhibited elevation of plasma endothelin immunoreactivity level, leakage of intracellular enzyme (lactate dehydrogenase) and release of myocardial lipid perox 1General Navy Hospital, Beijing 100037 2Phoenix Pharmaceuticals, Belmont, CA 94002 4041, USA idation products (MDA), decreased myocardial MDA and calcium content, and markedly prevented the decrease of cGMP levels in myocardium and vessel tissue, and obviously improved cardiac function. However, co administration of AdM (13～52) and LNNA, a specific nitric oxide synthase inhibitor, completely blocked the cardioprotective action of AdM (13～52), suggesting that the cardioprotective action of adrenomedullin may be mediated by NO." @default.
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- W2354108947 date "1996-01-01" @default.
- W2354108947 modified "2023-09-25" @default.
- W2354108947 title "Protective effect of adrenomedulin (13～52) on isoproterenol induced myocardial injury in rats" @default.
- W2354108947 hasPublicationYear "1996" @default.
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