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- W2354111628 abstract "Background and purpose:It was reported that erythropoietin may directly or indirectly induce the tumor cells to proliferate and result in diseases progression when recombinant human erythropoietin is used clinically in cancer-related anemia.Recently,the expression of erythropoietin-receptor (Epo-R) was detected in breast cancer.This study was done to detect the expression of Epo-R,estrogen receptor (ER),progesterone receptor (PR) and human epidermal growth factor receptor 2 (Her-2) in breast cancer,and to investigate the relationships between these indexes and the clinical significance.Methods:Sixty breast cancer patients were analyzed,the expression of Epo-R and microvascular density (MVD) were detected by immunohistochemistry,in order to clarify the relationships between the expression level of Epo-R,MVD and ER,PR,Her-2.Results:The rate of Epo-R expression was 78.3%,the mean number of positive tumor cells was 39±24,while the tissue MVD was 25±9.The expression level of Epo-R was positively correlated with the MVD.Also,the level of MVD was higher in the group of Epo-R positive than the negative,which has significant difference (t=3.4252,P0.001).The expression level of ER,PR has no definite relationships with Epo-R,MVD.The expression level of Her-2 was both closely associated with Epo-R,MVD.The expression level of Epo-R has an obvious relationship with clinical stage,lymph node status and the size (P0.001).The value of MVD was positively correlated with lymph node status,while not with clinical stage and the size.Conclusion:The expression level of Epo-R was markedly higher in breast cancer,and has a positive correlation with the tissue MVD.The expression level of Epo-R and MVD were significantly associated with Her-2,but not with ER and PR.It may contribute to clarifying the clinicopathological characteristics and prognosis of breast cancer by detecting both the expression level of Epo-R and MVD." @default.
- W2354111628 created "2016-06-24" @default.
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- W2354111628 date "2010-01-01" @default.
- W2354111628 modified "2023-09-23" @default.
- W2354111628 title "Expression of erythropoietin-receptor and the relationship between ER,PR and Her-2 in breast cancer" @default.
- W2354111628 hasPublicationYear "2010" @default.
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