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- W2354117085 abstract "Purpose To study the effects of MMP?2 and MT1?MMP expression in type Ⅱ pneumocytes during rat pulmonary fibrosis model induced by bleomycin. Methods Type Ⅱ pneumocytes were isolated in various periods of rat pulmonary fibrosis,and then the expression of MMP?2 and MT1?MMP mRNA were evaluated by RT?PCR quantitative analysis. Results (1) The expression of MMP?2 and MT1?MMP mRNA increased markedly at 1st and 7th day after bleomycin;(2) MMP?2 transcripts of alveolar type Ⅱ cells increased slightly in early stage of pulmonary fibrosis. Conclusions Type Ⅱ pneumocytes were not the only object of causative stimuli resulted in cell damage,but also involved in the development of pulmonary fibrosis by proliferation and secreting MT1?MMP,which activated pro MMP?2 and destroyed the pulmonary basement membrane afterwards." @default.
- W2354117085 created "2016-06-24" @default.
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- W2354117085 date "2001-01-01" @default.
- W2354117085 modified "2023-09-25" @default.
- W2354117085 title "Expression of MMP-2 and MT1-MMP in type II Pneumocytes during Rat Pulmonary Fibrosis Model Induced by Bleomycin" @default.
- W2354117085 hasPublicationYear "2001" @default.
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