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- W2354121211 abstract "Objective To investigate the changes of OX40L expression on human umbilical vein endothelial cells(HUVECs)and its effect on biological behavior of T cells under high glucose.Methods HUVECs were treated with glucose in the concentrations of 5.5,16.7 and 33.3mmol/L for 72h,respectively.DMEM was used as control group.The expression of OX40L was analysed by flowcytometry.The proliferation of T cells was measured by cell counting kit-8(CCK-8)assay after co-cultured with HUVECs pretreated with glucose 16.7mmol/L for 72h,which then was divided into six groups of A(T cells),B(incubated with anti-CD3),C(incubated with anti-CD3 and HUVECs),D(incubated with anti-CD3,HUVECs and anti-OX40Lmonoclonal antibody),E(incubated with antiCD3,HUVECs and glucose 16.7mmol/L),and F(incubated with anti-CD3,HUVECs,glucose 16.7 mmol/L and anti-OX40Lmonoclonal antibody).Results Compared with control group,the expression of OX40L was increased in a dose-dependent manner after treated with high glucose for 72h(P0.05).The proliferation of T cells in co-cultivation with HUVECs pre-treated with glucose 16.7 mmol/L was promoted(P0.05),which could be reduced by anti-OX40L monoclonal antibody(P0.05).Conclusion High glucose could up regulate OX40L expression on HUVECs and promote the proliferation of T cells through OX40/OX40 Lpathway." @default.
- W2354121211 created "2016-06-24" @default.
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- W2354121211 date "2013-01-01" @default.
- W2354121211 modified "2023-09-23" @default.
- W2354121211 title "Effect and significance of OX40L expression on human umbilical vein endothelial cells" @default.
- W2354121211 hasPublicationYear "2013" @default.
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