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- W2354137180 abstract "Objective To explore the effects and central mechanisms of oxymatrine(OMT) on injury induced by focal cerebral ischemia reperfusion in rats.Methods The focal cerebral ischemia reperfusion was induced by middle cerebral artery occlusion in rats.The rats injected by intraperitoneal were randomly divided into sham group,focal cerebral ischemia reperfusion model group,LLT 31.25 mg·kg-1 group,and OMT 35,70 and 105 mg·kg-1 groups.The rats injected by cerebral ventricle were randomly divided into sham group,focal cerebral ischemia reperfusion model group,LLT 0.15 mg·kg-1 group,and OMT 0.35 mg·kg-1 group.The neurological score and infarct areas were used to evaluate the protective effects of OMT in focal cerebral ischemia reperfusion rats.The NO content in serum was determined in focal cerebral ischemia reperfusion rats injected by cerebral ventricle.Results OMT 70 and 105 mg·kg-1 by intraperitoneal injection decreased neurological score(P0.05),deflated infarct areas(P0.05) compared with focal cerebral ischemia reperfusion model group.Compared with focal cerebral ischemia reperfusion model group,the infarct area and the NO content in serum were decreased in rats treated with OMT 0.35 mg·kg-1 by cerebral ventricle injection.Conclusion OMT injected by cerebral ventricle has protection against injury induced by cerebral ischemia reperfusion in rats.The central mechanism may be one of mechanisms of OMT." @default.
- W2354137180 created "2016-06-24" @default.
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- W2354137180 date "2008-01-01" @default.
- W2354137180 modified "2023-09-26" @default.
- W2354137180 title "Central mechanisms of protective effects of oxymatrine on injury induced by focal cerebral ischemia reperfusion in rats" @default.
- W2354137180 hasPublicationYear "2008" @default.
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