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- W2354139735 abstract "AIM To construct the expression vector of endostatin gene and transfect it into C6 cell, and to discuss its antiangiogenesis activity. METHODS The rat serum albumin secretive signal was linked to the endostatin gene C terminal by PCR, this fused gene was then inserted into polylinker sites of eukaryotic expression vector pcDNA3 to construct pcDNA SE. The vector was transfected into C6 glioma cells by lipofectamine and the positive clone was screened by G418. The activity of endostatin protein expressed by the C6 cells was examined by immunohistochemistry and the cellproliferation assay. RESULTS The eukaryotic expression vector pcDNA SE was successfully constructed and transfected into C6 cells. The cells expressed the endostatin protein which could inhibit the endotheliocyte proliferation. CONCLUSION Endostatin is a potent angiogenesis inhibitor. The experiment lays a foundation for following experiments on antiangiogenesis gene therapy of tumor." @default.
- W2354139735 created "2016-06-24" @default.
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- W2354139735 date "2001-01-01" @default.
- W2354139735 modified "2023-09-23" @default.
- W2354139735 title "Construction of the eukaryotic expression vector of endostatin gene and identification of its activity" @default.
- W2354139735 hasPublicationYear "2001" @default.
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