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- W2354192423 abstract "Objective: Acute hepatitis B virus(HBV) infection is followed by high viral replication rates leading to hepatocyte death and ultimately,in some cases,to acute liver failure(ALF) necessitating liver transplantation.Thus,the objective of our study is to observe the efficacy and safety of entecavir in patients with hepatitis B-associated acute liver failure.Methods: This prospective study(01/2011-06/2012) included 15 patients(3 female and 12 males,median age 33.5 years).HBV DNA and hepatitis B antigens and antibodies system were detected by ELISA or PCR.All patients received entecavir treatment at 0.5 mg daily after confirmed diagnose.Results: Upon treatment,all observed parameters rapidly decreased and returned to normal values or trace amounts(HBV DNA undetectable) within 2 months in all ofthe 8 cases except 5 cases whose condition deteriorated to die and 2 cases who got orthotopic liver transplantation.A seroconversion to anti-HBs was achieved in 7 out of 8 patients;one patient did not seroconvert.Conclusion: This preliminary series of 8 patients reveals that immediate treatment of HBV-induced ALF with entecavir is well tolerated and beneficially affects the course of the disease,improves prognosis,and even avoids liver transplantation." @default.
- W2354192423 created "2016-06-24" @default.
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- W2354192423 date "2012-01-01" @default.
- W2354192423 modified "2023-09-23" @default.
- W2354192423 title "Efficacy and Safety of Entecavir in Patients with Hepatitis B-Associated Acute Liver Failure" @default.
- W2354192423 hasPublicationYear "2012" @default.
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