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- W2354196566 abstract "Objective: Acute lung injury is a common severe disease clinically which characterized with urgent oncoming and high death rate. There are short of effective therapeutic methods treating acute lung injury. GYY4137, a new exogenous hydrogen sulfide donor, was shown to possess anti-inflammation, anti-shock, anti-cancer, and anti-thrombus effects. This study was to investigate the protective effects of GYY4137 on LPS induced acute lung injury and the mechanisms underlying. Methods: BALB/c mice(18-20 g) were randomly designated into 3 groups: normal control group(20), LPS treated group(20), and GYY4137 treatment group. The mice of acute lung injury group received an intraperitoneal administration of LPS(10 mg/kg). The mice of GYY4137 treatment group received a dose of GYY4137(50 mg/ kg, i.p.) after administration of LPS for an hour. The mice were sacrificed 8 hours after LPS treatment for. Serum samples and lung tissues were collected. The inflammatory cytokines of tumor necrosis factor α, interleukin 6, and interleukin 10 were analyzed. The concentration of H2 S in mice plasma was analyzed. The wet to dry ratio and myeloperoxidase activity of mice lungs was detected. The oxidative stress related factors H2O2,·OH, and SOD concentrations in mice lungs were also checked. Results: LPS induced severe acute lung injury. GYY4137 administration decreased lung edema, inflammatory response, and oxidative damages resulted by LPS. Treatment of GYY4137 protected LPS induced lung injuries, and the protective effects of GYY4137 may contribute to its anti-inflammation and anti-oxidative effects. Conclusion: GYY4137 protected mice from LPS-induced acute lung injury which may be related with its anti-inflammation and anti-oxidative effects. The slow-releasing H2 S donors may also exert the same activities in other models of inflammation, and may offer new basic information for clinical application." @default.
- W2354196566 created "2016-06-24" @default.
- W2354196566 creator A5022189337 @default.
- W2354196566 date "2014-01-01" @default.
- W2354196566 modified "2023-09-23" @default.
- W2354196566 title "A New Hydrogen Sulfide Donor,GYY4137,Alleviates LPS-induced Acute Lung Injury" @default.
- W2354196566 hasPublicationYear "2014" @default.
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