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- W2354199921 abstract "Objective To investigate the effects of miR-9 on the cells proliferation and migration of cervical cancer cells,and to detect the expression of the downstream genes.Methods miRNA mimics were transected into cervical cancer cell line Hela,and then the ability of cell growth and migration was determined by MTT and transwell assay.The mRNA microarrays was used to examine the expression of downstream genes of miR-9,and quantitative real-time reverse transcriptase PCR(qRT-PCR)was used to validated the expression of the genes.Results MTT assay showed that the proliferation rate of miR-9 group was significantly increased compare with NC and mock(P0.05).Cell migration assay showed the number of Hela cell that passed through the membrane in miR-9 group was significantly higher than NC group and mock group(P0.05).The mRNA Microarrays showed that totally 173 genes were down expression,and the FSTL1 and CDH1 were downexpressed most.The qRT-PCR result showed that the relative expression of FSTL1 and CDH1 in transected with miR-9 mimic group was significant decreased compare to the negative control group(P0.05).Conclusions Our results indicate that miR-9 promotes cervical cell Hela proliferation and migration,and regulates the expression of the downstream genes." @default.
- W2354199921 created "2016-06-24" @default.
- W2354199921 creator A5010682781 @default.
- W2354199921 date "2014-01-01" @default.
- W2354199921 modified "2023-09-23" @default.
- W2354199921 title "The effects of miR-9on the cervical cancer cells proliferation,migration and the expression of downstream genes" @default.
- W2354199921 hasPublicationYear "2014" @default.
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