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- W2354208382 abstract "OBJECTIVE: To analyze the drug sensitivity of the susceptible strains from different surgical groups of colorectal cancer patients and with the analytic results as reference to provide perioperative prophylactic antibiotic use regimens to reduce drug resistance and incidence of surgical site infection( SSI). METHODS: The susceptible strains isolated from one hundred and sixty-four colorectal cancer patients were identified using VITEK-32 automatic microbiological analyzer,and drug susceptibility test was performed and the results were judged in accordance with the guiding principle issued by CLSI. The drug susceptibility test on different bacteria from different surgical procedure was analyzed statistically. RESULTS: 33. 2%( 115 /346) of the isolated G-bacteria produced ESBLs,most of which were E. coli.( 43. 4%,96 /221). The E. coli from mucosal tissue,peritoneal fluid and fluid drainage samples were sensitive to Amikacin,Cefoxitin,Carbapenems and β-Lactamase-containing drugs and the susceptibility rates of the strains from fluid drainage all stood at 80%-100%. CONCLUSION: G-bacteria,mainly E. coli were the most commonly detected strain from three types of samples. The increase of drug resistance of E. coli in three samples in order( mucosa,intraoperative fluid to fluid one day after surgery) was associated with increasing in the isolating rate of ESBLs. ESBLs-producing E. coli were resistant to first,second,third and fourth generations of Cephalosporins but sensitive to Amikacin,Cefoxitin,β-Lactamase-containing drugs such as Piperacillin / Tazobactam,Imipenem and other Carbapenems. It is advisable to use Cephamycins that are effective to Enterobacteriaceae and anaerobic bacteria suchas Cefoxitin in the setting of perioperative prophylactic use. Metronidazole may be used concurrently if necessary in order to prevent anaerobic infection." @default.
- W2354208382 created "2016-06-24" @default.
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- W2354208382 date "2014-01-01" @default.
- W2354208382 modified "2023-09-23" @default.
- W2354208382 title "Drug Susceptibility of Susceptible Strains Isolated from Surgical Samples of Patients with Colorectal Cancer" @default.
- W2354208382 hasPublicationYear "2014" @default.
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