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- W2354214208 abstract "Objective To observe the effects of PPAR-γ ligand,GW1929 on the mice peritoneal macrophage foam cells formation and TLR-2,TLR-4 expression induced by oxLDL.Methods The mice peritoneal macrophages were pretreated with oxLDL(50 μg/mL) and GW1929(20 μmol/L) respectively for 24 h.Then they were stained by oil red O to observe foam cells formation.Then confocal fluorescence microscopy was used to observe effects of GW1929 on foam cells TLR-2 and TLR-4 expressions.Results The mice peritoneal macrophages of control group and GW1929 group are not almost stained by oil red O,but the macrophages of oxLDL group become dark red after stained by oil red O,and the cells color of oxLDL+GW1929 group is thinner than that of oxLDL group.Expressions of TLR-2,TLR-4 in oxLDL group are higher than those in control and GW1929 group obviously,but expressions in oxLDL+GW1929 group are lower than oxLDL group respectively.Conclusion PPAR-γ ligand,GW1929 probably stable atheromatous plaque through inhibiting foam cells foamation and expressions of TLR-2,TLR-4." @default.
- W2354214208 created "2016-06-24" @default.
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- W2354214208 date "2009-01-01" @default.
- W2354214208 modified "2023-09-27" @default.
- W2354214208 title "Effects of PPAR-γ Ligand on the Mice Peritoneal Macrophage Foam Cells Formation and TLR-2,TLR-4 Expression Induced by OxLDL" @default.
- W2354214208 hasPublicationYear "2009" @default.
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