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- W2354217157 abstract "Objective: To investigate the effects of etomidate injection pain and myoclonus given intranasal dexmedetomidine premedication on the induction of gereral anesthesia. Methods: Sixty cases undergone operation were randomly allocated to each group. Intranasal administrated dexmedetomidine1. 0 μg·kg- 1( group D n =30) or given same volume of saline( group N n = 30) 30 min before surgery. Blood pressure( BP),heart rate( HR),oxygen saturation( SPO2) were recorded before drug( T0),to etomidate before( T1) and to 1 min( T2) 、2 min( T3) after etomidate. Scoring method used words( VRS) for etomidate injection pain score; observed and recorded myoclonus occurrence within 2 min after intravenous etomidate. Results: There were no differences between two groups in all indexes before drug( P 0. 05). The SBP,HR,the VRS scores and myoclonus occurrence of group D were significantly lower than that of group N after drug( P 0. 05). SPO2had no statistical significance between the two groups before and after drug( P 0. 05). Conclusions:These results suggest that the intranasal administration of dexmedetomidine in patients before operation is a safe and effective preoperation medication,Not only can effectively reduce etomidate injection pain,but also significantly reduce myoclonus occurrence induced by etomidate to provide a more stable hemodynamic conditions." @default.
- W2354217157 created "2016-06-24" @default.
- W2354217157 creator A5063315923 @default.
- W2354217157 date "2014-01-01" @default.
- W2354217157 modified "2023-09-23" @default.
- W2354217157 title "Effects of intranasal dexmedetomidine pretreatment on induction of general anesthesia with etomidate" @default.
- W2354217157 hasPublicationYear "2014" @default.
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