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- W2354235280 abstract "Objective To explore the expression and distribution of IGF-1、IGF-1R and apoptosis-associated factors Bcl-2、Bax and their possible functions during the development of rat condyalr cartilage.Methods The 1、7、14 and 28-day-old rat condyles were obtained and their shape and structures were observed with toluidine blue stain method.The distribution of IGF-1、IGF-IR、Bcl-2 and Bax proteins on 1-、7-、14-and 28 day-old condylar cartilage were evaluated by immunohistochemistry.The expression of IGF-1、IGF-1R、Bcl-2、Bax mRNA and proteins in each group were investigated by real time PCR and western blot analysis.Results Toluidine blue staining showed the rapid developmental changes of rat condylar cartilages about thinner cartilage and thicker subchondral bone,and they were followed by rapid growth in condylar size.The immunohistochemical staining was positive for IGF-1、IGF-1R、Bcl-2,which was mainly located from the proliferation to upper hypertrophic layers.The distribution of Bax proteins were mainly on mature chondrocyes layers and hypertrophic layers.The result of real time PCR and western blot analysis showed that IGF-I mRNA expression levels strated to decrease immediately after the animals' birth,and increased from 28 days.IGF-IR protein and mRNA expression levels were relatively well maintained although there was some variation.Bcl-2、Bax protein and mRNA expression levels reached a peak at 14 days and thereafter decreased(P0.05).Conclusion IGF-1、IGF-1R and apoptosis-associated factors Bcl-2、Bax show analogously temporal expression and distribution,play a regulatory role in condylar cartilage development." @default.
- W2354235280 created "2016-06-24" @default.
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- W2354235280 date "2013-01-01" @default.
- W2354235280 modified "2023-09-23" @default.
- W2354235280 title "Expression and function of IGF-1、IGF-1R and Bcl-2、Bax during the development of rat condylar cartilage" @default.
- W2354235280 hasPublicationYear "2013" @default.
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