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- W2354238914 abstract "Objective To determine the expression of erythrocyte chemokine receptor (ECKR) on peripheral blood neutrophils of patients with psoriasis vulgaris and to explore its clinical significance.Methods ECKR on peripheral blood neutrophils was detected by direct immunofluorescence staining method. ECKR on neutrophils,which combined with FITC-labeled ECKR mAb,was detected by flow cytometry. Reverse transcription-polymerase chain reaction (RT-PCR) technique was applied to semi-quantatatively analyze ECKR mRNA expression in peripheral blood neutrophils from 28 cases of psoriatic patients,and 30 healthy controls.The correlation between ECKR and psoriatic aera and severity index (PASI) was evaluated.Results The results showed that the positive rate of and ECKR+ neutrophils in psoriasis was significantly lower than that in the controls (P0.01).The positive rate of ECKR+ neutrophils in active psoriasis was lower than that of resting psoriasis.Furthermore,the positive rate of ECKR+ neutrophils in psoriasis was closely related with PASI score of psoriasis.ECKR mRNA levels in neutrophils from psoriatic patients were markedly higher than those in normal controls.Conclusion ECKR may be regarded as clinical reference index to observe the change of the disease progress." @default.
- W2354238914 created "2016-06-24" @default.
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- W2354238914 date "2005-01-01" @default.
- W2354238914 modified "2023-09-24" @default.
- W2354238914 title "The Expression of Erythrocyte Chemokine Receptor on Peripheral Blood Neutrophils of Patients with Psoriasis Vulgaris" @default.
- W2354238914 hasPublicationYear "2005" @default.
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