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- W2354241938 abstract "Objective To research the involvement of the early active microglia and macroglia during the focal cerebral ischemia in rats. Methods The focal cerebral ischemia was established by occluding middle cerebral artery for 2hours and reperfusing 0.5~48hours. The immunohistochemical method was used to study TGF-β 1,NGF,and GDNF expression in active microglia and macroglia. Results In normal group and sham operated group,the microglia showed TGF-β 1 negative. At 3hours of reperfusion,Microglia in medullas showed weakly TGF-β 1 positive. At 6~48hours of reperfusion,Microglia in ischemic cortex,caudate putamen and preoptic area showed strongly TGF-β 1 positive. In normal group and sham-operated group,Microglia in medullas including internal capsule and corpus callosum appeared weakly NGF as well as GDNF weakly positive. At 48hours of reperfusion,the active microglia and macroglia of periinfarct area located in preoptic area showed GDNF moderately positive. In contrast,macroglia in meninges of preoptic area appeared NGF strongly positive at 0.5hour of reperfusion. A few of active microglia and macroglia in preoptic area,caudate putamen weakly expressed NGF at 12hours of reperfusion. Furthermore,the active microglia and macroglia in periinfarct strongly expressed NGF at 24~48hour of reperfusion. Conclusion Active microglia and macroglia strongly and orderly up-regulated the expression of TGF-,NGF,and GDNF. These data suggest that the active microglia and macroglia at early time of ischemia-reperfusion possible protect neurons from ischemic injury." @default.
- W2354241938 created "2016-06-24" @default.
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- W2354241938 date "2001-01-01" @default.
- W2354241938 modified "2023-09-24" @default.
- W2354241938 title "Increased TGF-β_1,NGF,and GDNF expression in active microglia and macroglia in focal cerebral ischemia in rats" @default.
- W2354241938 hasPublicationYear "2001" @default.
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