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- W2354266873 abstract "Objective:To investigate the efficacy of Jiangzhi Hugang capsule(JZHGJN) in the treatment of rat nonalcoholic steatohepatitis(NASH).Methods:Duplicate the animal steatohepatitis model with fat-rich and chol-rich diet.Sixty SD male rats were randomly divided into 3 groups including the therapy group,the model group and the mormal control group.Blood sample were collected for the detection of serum ALT,AST,TG,TC and liver tissues were obtained for the detection of SOD,MDA including TNF-α and IFN-γ levels.The pathological changes were observed under light microscope.Results:In comparison with those of normal rats,the contents of SOD were decreased significantly in the model rats but ALT,AST,TG,TC,MDA were increased significantly in the model group(P0.01).The above-mentioned markers were obviously improved in the medication rats(P0.01),and the degree of fatty degeneration was also alleviated.Conclusion:JZHGJN has definite effect on repairing the damage of hepatocyte and decreased the lever of the serum TG,TC;It can also increase the activity of SOD and reduce the content of MDA and prevent the activity of cytokine such as TNF-α,IFN-γ during inflammatory reaction and amend pathological damage in hepatic tissues.JZHGJN has significantly therapeutic effect on nonalcoholic steatohepatitis rats." @default.
- W2354266873 created "2016-06-24" @default.
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- W2354266873 date "2009-01-01" @default.
- W2354266873 modified "2023-09-26" @default.
- W2354266873 title "Experiment study on treatment of nonalcoholic fatty liver disease by capsule Jiangzhi Hugan" @default.
- W2354266873 hasPublicationYear "2009" @default.
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