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- W2354268632 abstract "The breast cancer is the most common malignancy of women.This risk is concerned with estroGen,environment and some specific Genes mutations. This study is to investigate the effects of breast cancer incidence rate and AIB1,C-erbB2 expression in breast cancer tissue on early rats treated with environmental estroGenic compounds such as Octylphenol (OP) and Genistein (Gen). Female Sprague-Dawley rats were randomly divided into control group,model group(Mod),OP20,OP40,OP80,and Gen.Octylphenol was given to rats via subcutaneous injection from d22 to d28. DMBA was given to rats via oral gavage on d42. Rats were killed on d220. There was no breast cancer in Con group. The incidence rate of breast cancer in OP20 ,OP40 ,OP80,Gen and Mod was 57.14%、28.57%、52.38%、23.81% and 66.67% respectively. Compared with Mod,40mg/kg OP and Gen decreased AIB1 and C-erbB2 mRNA expression significantly in breast cancer and lasted for a long time. The study suggests that OP40 and Gen can decrease DMBA-induced breast cancers,which may be related to down-regulation of AIB1 and C-erbB2 expression in breast cancer." @default.
- W2354268632 created "2016-06-24" @default.
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- W2354268632 date "2010-01-01" @default.
- W2354268632 modified "2023-09-24" @default.
- W2354268632 title "Prepubertal Octylphenol Exposures Can Down-regulate AIB1 and C-erbB2 Expression and Reduce the Breast Cancer in Rats" @default.
- W2354268632 hasPublicationYear "2010" @default.
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