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- W2354278649 abstract "Objective To explore the feasibility of low-dose ultrasound irradiation combined with microbubbles in myocardium ablation of canine in vivo.Methods Twenty canines were randomly divided into ultrasound+microbubbles(US+ MB) group,ultrasound(US) group,microbubbles(MB) group and control group(each n=5).The intracardiac echocardiography(ICE) catheter was delivered into left ventricle.In US+MB group,canine myocardia were exposed to ultrasound irradiation(0.3W / cm 2) for 30safter intramyocardial injection of 0.1ml microbubbles at anterior wall of left ventrium.Animals in US group and MB group received simple ultrasound irradiation or microbubbles injection,respectively,while in control group received catheterization only without other management.All the animals were executed on the 3th day.The myocardium was harvested for morphological and histological observation.Results Pale ablation lesions were observed at the region of microbubbles injection with visual inspection,and nuclear condensation and fragmentation in cardiac muscle cells were found under microscope in US+MB group.No obvious abnormality of the myocardia was found in US group,nor in MB group.Conclusion Microbubbles can increase the efficiency of ultrasound ablation,achieving myocardium ablation under low ultrasound energy,improving the safety of myocardium ablation." @default.
- W2354278649 created "2016-06-24" @default.
- W2354278649 creator A5083976719 @default.
- W2354278649 date "2013-01-01" @default.
- W2354278649 modified "2023-10-12" @default.
- W2354278649 title "Ultrasound irradiation combined with microbubbles in myocardium ablation of canine in vivo" @default.
- W2354278649 hasPublicationYear "2013" @default.
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