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- W2354293717 abstract "To study the effect of autophagy inducer rapamycin (RAPA) on the interaction between Salmonella typhi plasmid pRST98 and macrophage,strain J774A.1 of macrophages was cultivated in RPMI 1640 medium with RAPA or without overnight,and then Salmonella typhi carrying pRST98,ST8and Salmonella typhi without pRST98,ST10 and Salmonella typhimurium strain SR-11 carrying a 100 kb virulence plasmid were added. The situation of autophagy and apoptosis of cells was observed. It was showed that the number of autophagy vacuoles at 2 and 4 hrs after staining with MDC was SR-11 groupST8groupST10 group,and the number increased after the treatment with RAPA. The expression of Beclin-1 at 2 hr was SR-11 groupST8 groupST10 group,and the tendency appeared at 0 h time point after RAPA treatment;the apoptosis rate displayed a tendency of SR-11 groupST8 groupST10 group. After interference with RAPA the apoptosis rate of ST8decreased,meanwhile ST10 increased (P0. 05). The observation by transmission electron microscope showed that bacteria were surrounded by a bilayer membrane at 2～4 hrs,and apoptosis was observed from 8 hrs. while the infection of ST8 lessened,the infection of ST10 was aggratated with RAPA treatment. All these results suggest that pRST98 can inhibit autophagy at an early stage and RAPA can reduce the apoptosis induced by Salmonella typhi carrying pRST98,but enhance the apoptosis caused by Salmonella typhi without pRST98." @default.
- W2354293717 created "2016-06-24" @default.
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- W2354293717 date "2010-01-01" @default.
- W2354293717 modified "2023-09-24" @default.
- W2354293717 title "Effect of rapamycin on the interaction between Salmonella typhi plasmid pR_(ST98) and macrophages" @default.
- W2354293717 hasPublicationYear "2010" @default.
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