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• W2354293837 abstract "Objective To investigate the characteristics of bone mineral density( BMD) in patients with uremia and severe secondary hyperparathyroidism( SHPT),and to analyze the possible relationship between the changes of BMD and clinical features.Methods Fifty one patients with uremia and severe SHPT,who underwent total parathyroidectomy with forearm autotransplantation,were enrolled in this study. The clinical data of all the patients,including the general condition,clinical feature,BMD of the proximal femur and the lumbar vertebrae,and the weight of parathyroids from surgery,were retrospectively analyzed. BMD of the lumbar vertebrae( L1-L4) and the proximal femur was compared in the patients with the same gender. The correlation analysis between the decrease of BMD and multiple variables was also performed. Results Pruritus,osteodynia,facial deformations,short statures,thoracocyllosis,spine malformations,and bowlegs were found in all or part of the patients with high serum iPTH level of 2227. 9 ±907. 3pg /ml. Twenty-seven( 52. 9%) patients had osteoporosis,and 23( 45. 1%) patients had osteopenia. BMD of L1-L4declined gradually in men and women,while the T value of L4 was significantly lower than that of L1( P = 0. 037 in men and P =0. 039 in women). The T values of the femoral trochanter,the femoral neck,and the Ward's triangle also declined gradually. The T value of Ward's triangle was significantly lower than that of the femoral trochanter( P = 0. 025) in men,while the T values of Ward's triangle and the femoral neck were significantly lower than that of the femoral trochanter( P = 0. 009 and P = 0. 023) in women. BMI and serum albumin level were positively correlated with BMD. Shorten statures, thoracocyllosis, spine malformations,facial deformation,serum alkaline phosphatase level,serum iPTH level,and parathyroid weight were negatively correlated with BMD. Conclusion Osteoporosis and osteopenia are widely observed in patients with uremia and severe SHPT. The decrease of BMD in patients is more likely to appear in the bearing parts. Emaciation,low serum albumin levels,facial deformation,trunk malformation,high serum iPTH level,and large weight of parathyroid glands may indicate the increased risk of osteoporosis in patients with uremia and severe secondary hyperparathyroidism." @default.
• W2354293837 created "2016-06-24" @default.
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• W2354293837 date "2014-01-01" @default.
• W2354293837 modified "2023-09-24" @default.
• W2354293837 title "The characteristics of bone mineral density in patients with uremia and severe secondary hyperparathyroidism" @default.
• W2354293837 hasPublicationYear "2014" @default.
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