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- W2354310151 abstract "Objective To investigate the influence of anticonvulsants on neuromuscular blockade vecuronium and clinical dosage of vecuronium.Methods Forty patients(ASA grade Ⅰ-Ⅱ) scheduled for selective neurosurgery,were allocated into two group,group A(n=19) without any anticonvulsant administration as control,group B(n=21) with the anticonvulsant for 10 to 20 years.Anesthesia was maintained with isoflurane(IMAC).After TOF returned to 8%,vecuronium was intravenously infused at 0.03mg/(kg·h),and then adjusted at any time to maintain 8%≤TOF≤12%.Neuromuscular blockade was monitored with TOF accelegraphy.Results Total dosage of vecuronium in group A and B were 1.90±0.10mg/h and 2.90±0.20mg/h respctively,with differences between two groups(P0.05).Durations of TOF recovery to 25%,75% and recovery index after the infusion withdrawal were 7.30 ±1.50, 45.75 ±3.51,38.45±2.01 repectively in group A and 5.06± 2.12, 31.05 ±3.90,25.66±1.78 respectively in group B,with differences between two groups(P0.05).Conclusions Long-term administration with anticonvulsants before surgery can greatly reduce the neuromuscular blocking action of vecuronium during operation,shorten recovery of the neuromuscular blocking action." @default.
- W2354310151 created "2016-06-24" @default.
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- W2354310151 date "2003-01-01" @default.
- W2354310151 modified "2023-09-23" @default.
- W2354310151 title "Influences of anticonvulsants on the neuromuscular blocking of an intravenous infusion of vecuronium" @default.
- W2354310151 hasPublicationYear "2003" @default.
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