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- W2354314851 abstract "Objective:To explore the effects of Huoxue Qianyang formula on content of angiotensinⅡ,MMP-3 and TIMP-1 in blood serum of Spontaneous Hypertension Rat(SHR).Methods:Seventy-two SHRs were randomly devided into SHR control(SHR-C) group,Huoxue Qianyang formula(SHR-H) group,Valsartan(SHR-V) group and combination of Huoxue Qianyang formula and Valsartan(SHR-HV) group.Twenty Wistar-Kyoto(WKY) rats served for normal controls.The half of rats in every group were observed respectively for seven or fourteen weeks.After different courses of treatment,content of angiotensinⅡ,MMP-3 and TIMP-1 in blood serum were measured.Results:Serum content of angiotensinⅡ,MMP-3 and TIMP-1 were higher in the SHR-C group than those in the WKY group.They were lower in SHR-H group than those in the SHR-C group after fourteen weeks.Serum content of MMP-3 and TIMP-1 were lower in SHR-V group too,but angiotensinⅡ was higher in SHR-V group than that in SHR-C group,and the effects were more evidently after fourteen weeks than seven weeks.Serum content of MMP-3 in SHR-HV was the lowest in all SHR,and was close to the content in WKY.Conclusion:Huoxue Qianyang formula can lower serum content of angiotensinⅡ,MMP-3 and TIMP-1 of SHR,and ameliorate reconstitution of interstitial substance of LV.It can be one of mechanism which Huoxue Qianyang formula reverse left ventricular hypertrophy in essential hypertension." @default.
- W2354314851 created "2016-06-24" @default.
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- W2354314851 date "2009-01-01" @default.
- W2354314851 modified "2023-09-24" @default.
- W2354314851 title "Effects of Huoxue Qianyang Formula on Content of AngiotensinII MMP-3 and TIMP-1 in Blood Serum of Spontaneous Hypertension Rat" @default.
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