Matches in SemOpenAlex for { <https://semopenalex.org/work/W2354328400> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2354328400 abstract "A three-dimensional pharmacophore model was generated for aldose reductase(ALR2)inhibitors with flavonoid skeleton,using the software Catalyst.Specially customized features of hydrogen-bond acceptor and donor were used in this study,which perform better than the default features of Catalyst.The hypothesis model was scored based on the cost of the hypothesis from the null hypothesis.The final selected pharmacophore model had three features;one hydrogen bond acceptor and two donors.Six flavonoid compounds were used to dock into ALR2 active site,using InsightII/Affinity.Comparison between the pharmacophore model and the docking results suggested that the C7 and C4' hydroxyls on the flavone skeleton were key functional groups influencing ALR2 inhibotory activity,and TYR48,VAL47,GLN49,HIS110,and TRP111 at the active site of ALR2 were the key residues for the binding." @default.
- W2354328400 created "2016-06-24" @default.
- W2354328400 creator A5000227202 @default.
- W2354328400 date "2007-01-01" @default.
- W2354328400 modified "2023-09-23" @default.
- W2354328400 title "Flavonoids with Aldose Reductase Inhibiting Activity:Pharmacophore Modeling and Implications for Mechanism" @default.
- W2354328400 hasPublicationYear "2007" @default.
- W2354328400 type Work @default.
- W2354328400 sameAs 2354328400 @default.
- W2354328400 citedByCount "0" @default.
- W2354328400 crossrefType "journal-article" @default.
- W2354328400 hasAuthorship W2354328400A5000227202 @default.
- W2354328400 hasConcept C112887158 @default.
- W2354328400 hasConcept C159110408 @default.
- W2354328400 hasConcept C178790620 @default.
- W2354328400 hasConcept C181199279 @default.
- W2354328400 hasConcept C185592680 @default.
- W2354328400 hasConcept C21951064 @default.
- W2354328400 hasConcept C2776439734 @default.
- W2354328400 hasConcept C2778004101 @default.
- W2354328400 hasConcept C2779054382 @default.
- W2354328400 hasConcept C32909587 @default.
- W2354328400 hasConcept C41183919 @default.
- W2354328400 hasConcept C41685203 @default.
- W2354328400 hasConcept C55493867 @default.
- W2354328400 hasConcept C56173144 @default.
- W2354328400 hasConcept C70721500 @default.
- W2354328400 hasConcept C71240020 @default.
- W2354328400 hasConcept C71924100 @default.
- W2354328400 hasConcept C86803240 @default.
- W2354328400 hasConceptScore W2354328400C112887158 @default.
- W2354328400 hasConceptScore W2354328400C159110408 @default.
- W2354328400 hasConceptScore W2354328400C178790620 @default.
- W2354328400 hasConceptScore W2354328400C181199279 @default.
- W2354328400 hasConceptScore W2354328400C185592680 @default.
- W2354328400 hasConceptScore W2354328400C21951064 @default.
- W2354328400 hasConceptScore W2354328400C2776439734 @default.
- W2354328400 hasConceptScore W2354328400C2778004101 @default.
- W2354328400 hasConceptScore W2354328400C2779054382 @default.
- W2354328400 hasConceptScore W2354328400C32909587 @default.
- W2354328400 hasConceptScore W2354328400C41183919 @default.
- W2354328400 hasConceptScore W2354328400C41685203 @default.
- W2354328400 hasConceptScore W2354328400C55493867 @default.
- W2354328400 hasConceptScore W2354328400C56173144 @default.
- W2354328400 hasConceptScore W2354328400C70721500 @default.
- W2354328400 hasConceptScore W2354328400C71240020 @default.
- W2354328400 hasConceptScore W2354328400C71924100 @default.
- W2354328400 hasConceptScore W2354328400C86803240 @default.
- W2354328400 hasOpenAccess W2354328400 @default.
- W2354328400 hasRelatedWork W1559712878 @default.
- W2354328400 hasRelatedWork W166394182 @default.
- W2354328400 hasRelatedWork W1893742774 @default.
- W2354328400 hasRelatedWork W2024632615 @default.
- W2354328400 hasRelatedWork W2030919955 @default.
- W2354328400 hasRelatedWork W2031433562 @default.
- W2354328400 hasRelatedWork W2079286886 @default.
- W2354328400 hasRelatedWork W2095678848 @default.
- W2354328400 hasRelatedWork W2097165570 @default.
- W2354328400 hasRelatedWork W2099528710 @default.
- W2354328400 hasRelatedWork W2109402714 @default.
- W2354328400 hasRelatedWork W2255166890 @default.
- W2354328400 hasRelatedWork W2347920443 @default.
- W2354328400 hasRelatedWork W2355056511 @default.
- W2354328400 hasRelatedWork W2368872370 @default.
- W2354328400 hasRelatedWork W2379032530 @default.
- W2354328400 hasRelatedWork W2469199370 @default.
- W2354328400 hasRelatedWork W2474280399 @default.
- W2354328400 hasRelatedWork W2603164813 @default.
- W2354328400 hasRelatedWork W3194387421 @default.
- W2354328400 isParatext "false" @default.
- W2354328400 isRetracted "false" @default.
- W2354328400 magId "2354328400" @default.
- W2354328400 workType "article" @default.