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- W2354328804 abstract "Objective To study the remote protection of double rear legs ischemic preconditioning on spinal cord injury following ischemia and reperfusion. Methods The spinal cord ischemia/reperfusion model was made by clamping the infrarenal aorta in rabbits. The IPC group underwent three cycles of 5 minutes of hemostatic strip ligating double rear legs ,5 minutes loosing and 35 minutes of ischemia by clamping the infrarenal aorta. In the ischemia group, the abdominal aorta was occlused for 35 minutes and then reperfused. Neurological outcome was scored after reperfusion. Spinal cord histopathology and apoptosis were examined.The level of IL-8 was measured. Results The neurological function scores at all the time points were significantly higher than those in ischemia group. Histopathologic results were obviously better in IPC group than in ischemic group. The numbers of apoptosis neurons and IL-8 levels significantly decreased at the same time points in contrast to those in ischemic group. Conclusions Double rear legs IPC can protect spinal cord function from ischemia injury by an endogenous cellular protective mechanism. [" @default.
- W2354328804 created "2016-06-24" @default.
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- W2354328804 date "2005-01-01" @default.
- W2354328804 modified "2023-09-23" @default.
- W2354328804 title "Experimental study on the remote protective effects of ischemic preconditioning on spinal cord ischemia/reperfusion in rabbits" @default.
- W2354328804 hasPublicationYear "2005" @default.
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