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- W2354334705 abstract "Objective To study the mechanism of emodin on ischemia and reperfusion injury in canine autologous renal transplantation. Methods 18 Healthy mongrel dogs were randomly divided into sham group, emodin group, and normal saline group with 6 dogs in each group. Sham group received kidney operation resection. Dogs in emodin group were injected dosage of 10 mg/kg emodin at 2 h before surgery by intraperitoneal injection, and normal saline group with the method using the same volume. MDA, MPO, SOD, iNOS, and eNOS activity were detected after reperfusion after 1 h, and postoperative serum creatinine(Cr) and blood urea nitrogen(BUN) concentration and the level of TNF- α, IL-6, IL-8, and IL-10 inflammatory factor after 24 h were determined. Renal tissues were observed under light microscope pathological changes. Results The content of MDA, iNOS, BUN, Cr, TNF-α, IL-6, and IL-8 in normal saline group was significantly higher than that in sham group, while the content of MPO, SOD, eNOS, and IL-10 on the contrary(P0.05). The content of MDA, iNOS, BUN, Cr, TNF-α, IL-6, and IL-8 in emodin group was significantly lower than that in normal saline group, while the contents of MPO, SOD, eNOS, and IL-10 on the contrary(P0.05). Renal injury in emodin group were significantly reduced. Conclusion Emodin can alleviate the ischemia reperfusion injury in renal transplantation, and the mechanism may be related to reduce renal lipid peroxidation and inhibition of inflammatory factor." @default.
- W2354334705 created "2016-06-24" @default.
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- W2354334705 date "2014-01-01" @default.
- W2354334705 modified "2023-09-25" @default.
- W2354334705 title "Protective effect of emodin on ischemia reperfusion injury of kidney autotransplantation" @default.
- W2354334705 hasPublicationYear "2014" @default.
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