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- W2354339924 abstract "Objective:To evaluate the effect of recombinant human glail growth factor Ⅱ(rhGGF2) on recovery of motor function of rat sciatic nerve following crush injury.Methods:73 rats were divided into three groups.A sham operation was performed in group Ⅰ(n=5).A 5-mm segment of sciatic nerve was subjected to a 100g crush load for 2 hours in groups Ⅱ (n=34) and Ⅲ (n=34).Group Ⅲ was treated with rhGGF2 (1mg/kg by subcutaneous injection after crush for four days),and group Ⅱ was given the same volume of vehicle,Motor functional recovery was assessed by calculating the sciatic functional index(SFI) and measuring tetanic contractile force of extensor digitorum longus (EDL).Results:Group Ⅲ exhibited a significant improvement of SFI on postoperative day 11 to 21 when compared to group Ⅱ.The EDL contractile force was generally stronger in group Ⅲ than in group Ⅱ,with a significant difference at 70 and 100 Hz stimulus frequencies from day 4 to 14.Histological sections of nerve revealed less axonal degeneration and earlier regeneration of nerve in group Ⅲ.Conclusion:Treatment with rhGGF2 is effective in promoting nerve regeneration,as a result,can significantly improve the functional recovery of rat sciatic nerve following crush injury." @default.
- W2354339924 created "2016-06-24" @default.
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- W2354339924 date "2000-01-01" @default.
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- W2354339924 title "Glial Growth Factor Accelerates Functional Recovery of Injured Peripheral Nerve" @default.
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