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- W2354345204 abstract "The present studies investigated the effects of Methylparathion(MP) on the intracellular Ca~(2+) in the BRL cells.The cells were loaded with 10 μmol/L Fluo3/AM,and measured the [Ca~(2+)]_i by laser confocal scanning microscope (LCSM).The results suggested that MP concentration-dependence induced a increase of [Ca~(2+)]_i in normal physiology saline solution(N-PSS);When the solution changed to 0Ca~(2+)-PSS,400×10~(-6) MP have no effect on the [Ca~(2+)]_i.But there was a significant increase of [Ca~(2+)]_i while the solution was changed from 0Ca~(2+)-PSS to N-PSS.The MP-induced [Ca~(2+)]_i was found to be blocked by several non-selective cation channel blockers,such as 300μmol/L Gd~(3+),2mM Sr~(2+),and 2mM Ni~(2+).We also observed the difference between ATP-induced [Ca~(2+)]_i and MP-induced _i,the MP-induced a longer increase of [Ca~(2+)]_i than ATP did.These results suggested that MP could activated the non-selective cation channels,then lead to a significant Ca~(2+) influx through Ca~(2+) channels." @default.
- W2354345204 created "2016-06-24" @default.
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- W2354345204 date "2006-01-01" @default.
- W2354345204 modified "2023-09-26" @default.
- W2354345204 title "Mechanisam of Methylparathion-induced Intracellular Ca~(2+)Increase" @default.
- W2354345204 hasPublicationYear "2006" @default.
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