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- W2354345323 abstract "Objective To observe the effect of therapy of clearing heat,nourishing yin and expelling pathogens on vascular injury in spontaneous systemic lupus erythematosus MRL/lpr mice.Methods Twenty-four female MRL/lpr mice aged 8-10 weeks were equally randomized into 4 groups,i.e.,Chinese medicine group,western medicine group,Chinese and western medicine group,and model group.Six female healthy BALB/C mice aged 8-10 weeks were in the normal control group.Chinese medicine group was given gastric gavage of herbal mixture with the actions of clearing heat,nourishing yin and expelling pathogens(9.5 g·kg~-1·d~-1),western medicine group was given prednisone(10 mg·kg~-1·d~-1),Chinese and western medicine group was given the herbal mixture and prednisone,and the model group was given normal saline.The treatment lasted 6 weeks.No medication was given for the normal control group.Six weeks later,serum soluble thrombomodulin(sTM) and von Willebrand factor(vWF)levels were detected,and the renal pathological changes in mice were also observed under transmission electron microscope.Results Serum sTM and vWF levels were higher in the model group than those in the normal control group(P0.01).Compared to the model group,sTM and vWF levels were decreased in the medication groups,and the decrease of vWF was obvious in western medicine group(P0.05 or P0.01).The renal pathological changes were relieved to various degrees in the three medication groups.Conclusion The therapy of clearing heat,nourishing yin and expelling pathogens shows certain protective effect on vascular endothelia by decreasing serum sTM and vWF levels,and on relieving the renal pathological changes of chronic inflammation in MRL/lpr mice." @default.
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- W2354345323 date "2012-01-01" @default.
- W2354345323 modified "2023-09-25" @default.
- W2354345323 title "Effect of Therapy of Clearing Heat,Nourishing Yin and Expelling Pathogens on Vascular Injury Factor in Spontaneous Systemic Lupus Erythematosus Mice" @default.
- W2354345323 hasPublicationYear "2012" @default.
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