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- W2354347273 abstract "Objective: We probe into the pentadecapeptide BPC-157 induced function alterations of human umbili cal vein endothelial cells(HUVEC) and the underlying mechanism.Methods: First,we screened the BPC-157 re lated signal pathways by microarray;then,real-time PCR had been executed to affirm that BCP-157 could regu late several signal molecules expression on mRNA level which involve in the collected signal pathways;at last,the phosphorylation level of the pathways was detected by Western-blot.Results: After 10 μg/mL BPC-157 treat ed HUVEC for 24 h,microarray which includes 96 key genes belonged to 18 different pathways showed that 4 genes level had been regulated.c-Fos,c-Jun and Egr-1,three important molecules pertain to MAPK pathway,were significantly up regulated.BPC-157 also could enhance the expression of the three immediate early genes even in a low dosage(1 μg/mL).The phosphorylated ERK1/2 and p38 all enriched in HUVEC treated by 10 μg/ mL BPC-157 for 30 min.Conclusion: BPC-157 promotes the proliferation and migration of human umbilical vein endothelial cells may attribute to its activated stimulation of MAPK signal pathway and immediate early genes ex pression." @default.
- W2354347273 created "2016-06-24" @default.
- W2354347273 creator A5040027560 @default.
- W2354347273 date "2013-01-01" @default.
- W2354347273 modified "2023-09-25" @default.
- W2354347273 title "Involvement of p38 MAPK Pathway in BPC-157-Induced Promo tion of Proliferation and Migration in Human Umbilical Vein Endo thelial Cells" @default.
- W2354347273 hasPublicationYear "2013" @default.
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