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- W2354367062 abstract "Objective To study the effects of rapamycin(RAPA) which inhibition of mammalian target of RAPA(mTOR) combined with docetaxel(DOC) on proliferation and apoptosis of lung cancer cell lines A549,SPC-A-1,95D and NCI-H446.Methods The effect on the proliferation of lung cancer cells in different concentration RAPA group,DOC group and DOC combined with 20.0 nmol·L-1 RAPA group were evaluated using methyl thiazolyl tetrazolium(MTT) method,and 95D lung cancer cell apoptosis in three groups were measured by flow cytometry.Results RAPA could inhibit the lung cancer cell proliferation and its role in a dose-dependent fashion.DOC alone and DOC combined with 20.0 nmol·L-1 RAPA could inhibit the lung cancer cell proliferation,and inhibition rate of combined application significantly increased(P0.05).Flow cytometry shown that RAPA and DOC could increase the apoptosis ratio of 95D lung cancer cell(P0.05),and inhibition rate of combined application significantly increased(P0.05).Conclusion mTOR pathway may be involved in proliferation and apoptosis of lung cancer cells.Inhibition of mTOR,RAPA can enhance the anti-tumor effect of DOC." @default.
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- W2354367062 date "2012-01-01" @default.
- W2354367062 modified "2023-09-26" @default.
- W2354367062 title "Effects of rapamycin and docetaxel on proliferation and apoptosis of human lung cancer cell" @default.
- W2354367062 hasPublicationYear "2012" @default.
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