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- W2354367566 abstract "Aim: To study the acute toxicity of three Cobra Venom(CV) preparations and their inhibitory effect on transplanted hepatoma in mice. Methods: The acute toxicity test was designed accor ding to the Bliss method. Mice were orally given different dose of three CV preparations. The acute toxi city was observed. After the 24 hours of the inoculation of mouse hepatoma H 22, three CV preparations were given orally in a dose of the 1/3 of LD 1 for 9 days. The inhibitory rates of tumor were calculated from its weight change. Results: LD 50 and 95% Conf.Lim.of three preparations were respectively 5 410 mg·kg -1 (4 650～6 290 mg·kg -1), 52.94 mg·kg -1 (42.07～66.63 mg·kg -1) and 97.45 mg·kg -1 (83.62～113.56 mg·kg -1). In two experiments, the tumor weight inhibitory rates of the serum preparations were 35.5%?32.9%. Those of the others were 22.9%?20.3% and 25.3%?21.3%. Body weights of mice were markedly increased after the drug administration in all groups. Conclusion: After the CV was denatured or digested, its anticancer activity was still remained. The toxicity of the serum preparations was lowered than that of the others, but the tumor inhibitory effect more remarkable." @default.
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- W2354367566 date "2002-01-01" @default.
- W2354367566 modified "2023-09-25" @default.
- W2354367566 title "Acute toxicity test of three Cobra Venom preparations and their inhibitory effect on transplanted hepatoma in mice" @default.
- W2354367566 hasPublicationYear "2002" @default.
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