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- W2354384000 abstract "Objective To investigate the value of quantitative determination of anti-double stranded DNA(ds-DNA) for systemic lupus erythematosus(SLE) diagnosis and therapy in clinical application.Methods Serum from 77 patients with SLE(37 patients were in active stage,40 patients were in remission stage),74 patients of other connective tissue disease and 68 healthy people were collected.Enzyme-linked immune absorbent assay(ELISA)was used to test ds-DNA antibody,and we observed the different results of three groups.The levels of ds-DNA,complement C3,C4,erythrocyte sedimentation rate(ESR) of 36 patients in active stage were tested before and after treatment in 3,7,14,20 days,then we compared the sensitivity of these items.Results There was a significant difference between the level of ds-DNA antibody in active,remission SLE groups and that of health controls(P0.01),there was no significant difference between the level of ds-DNA antibody in other connective tissue group and that of the health controls(P0.05).The ds-DNA antibody level of 36 patients in active stage decreased 3 days after treatment,the result showed a significant difference(P0.05),and there was a significant difference of the level of C3 and ESR before and 14 days after treatment(P0.05).But the result of C4 level before and after treatment showed no significant difference(P0.05).Conclusion ds-DNA antibody has high sensitive and specificity on diagnosing the SLE.And it decreases more quickly than the non-specificity items of C3,C4 and ESR after the effective treatment.So quantitative determination of the ds-DNA antibody has a higher value in clinical application." @default.
- W2354384000 created "2016-06-24" @default.
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- W2354384000 date "2011-01-01" @default.
- W2354384000 modified "2023-09-22" @default.
- W2354384000 title "Observation of the quantitative determination of anti-double stranded DNA on diagnosis and treatment of systemic lupus erythematosus" @default.
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