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- W2354401610 abstract "Objective:To establish an RP-HPLC method to determine 3'-FUDR-4-(3-(3,5-di-tert- butyl-4-methoxyphenyl)-3-oxoprop-1-enyl)benzoate(3'-FUDR-BOBA)and its stability in different pH buffer solution and biological media.Method:The samples were determined on a Diamonsil C_(18)column(150 mm×4.6 mm,5μm),with the mobile phase of methanol-water(85:15).The flow rate was 1 mL·min~(-1),and the UV detection was set at 270 nm.The degradation of 3'-FUDR-BOBA in different pH buffer solution and in homogenate of mice were determined.Results:The linearity range was 0.1～100μg·mL~(-1),regression equation was A=2.039×10~4C+2.259×10~3(r=0.9998).The half life(t_(1/2))in homogenate of serum,liver,kidney and lung were 12.6,0.99,1.64 and 4.48 h,respectively.Conclusion:3'-FUDR-BOBA is stable in acidic and neu- tral solution,and easily hydrolyzed in alkaline solution;it is easily hydrolyzed in homogenate of liver and kidney of mice." @default.
- W2354401610 created "2016-06-24" @default.
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- W2354401610 date "2008-01-01" @default.
- W2354401610 modified "2023-09-25" @default.
- W2354401610 title "Study on stability of 3'-FUDR-BOBA by RP-HPLC" @default.
- W2354401610 hasPublicationYear "2008" @default.
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