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- W2354419397 abstract "Objective To compare the antihypertensive effects of candesartan and felodipine and their influences on the levels of plasma urotensin Ⅱ(U Ⅱ) and adiponectin(ADI) in the patients with hypertension complicating type 2 diabetes.MethodsThe patients(n=84) were chosen and randomly divided into candesartan group(4 mg, qd) and felodipine group(5 mg, qd) and treated for 16 weeks. The antihypertensive efficacies of these two drugs were compared. The levels of plasma U Ⅱ, ADI and angiotensin Ⅱ(Ang Ⅱ) were detected by applying enzyme-linked immunosorbent assay(ELISA) and radioimmunoassay before and after treatment. The influences of these two drugs on the above-mentioned vasoactive substances were observed.ResultsThe level of blood pressure decreased in tow groups after treatment but there was no statistical difference between two groups. The levels of U II, ADI and Ang Ⅱ had no statistical difference between two groups before treatment(P0.05), and after treatment for 16 weeks, in candesartan group, compared with felodipine group, U II level decreased significantly [(6.17±1.45)pmol/Lvs.(8.92±1.21) pmol/L,P0.01], ADI level increased significantly [(6.13±1.45) mg/Lvs.(4.12±1.46)mg/L,P0.01], and Ang Ⅱ level had no statistical difference between two groups [(149.72±22.89) mg/Lvs.(143.27±23.88) mg/L,P0.05].ConclusionCandesartan is superior to felodipine in reducing the levels of U Ⅱ and ADI in the patients with hypertension complicating type 2 diabetes." @default.
- W2354419397 created "2016-06-24" @default.
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- W2354419397 date "2013-01-01" @default.
- W2354419397 modified "2023-09-28" @default.
- W2354419397 title "Influences of candesartan on plasma urotensin II and adiponectin in patients with hypertension complicating type 2 diabetes" @default.
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