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- W2354430892 abstract "Objective: To study the effects of hypoxia and hypoxia training on the expressions of CPT-1 mRNA and protein in AMPKα2 transgenic mice skeletal muscle.Furthermore,we explore the possible mechanism of AMPKα2 in regulating fatty acid oxidation during hypoxia and hypoxia training.Methods: Healthy C57BL/6J wild-type(WT) mice and AMPKα2 transgenic(TG) mice,two months old,were randomly divided into control groups,hypoxia groups and hypoxia training groups each.Hypoxia groups and hypoxia training groups were exposed in the hypoxia room the whole day for two weeks(simulation of 4000m altitude,oxygen concentration 12.3%),and meanwhile hypoxia training groups were trained to run on the treadmill(12 m/min,1h/day).After that,quadriceps femoris muscle were removed,and then the expression of AMPKα2 protein and CPT-1 mRNA and protein were measured.Results: Either hypoxia or hypoxia training had no effect on the expression of AMPKα2 protein;both hypoxia and hypoxia training significantly increased CPT-1 mRNA expression(P0.05);in hypoxia groups,there was no apparent difference in CPT-1 expression between WT and TG mice;after two weeks hypoxia training,the expression of CPT-1 mRNA of TG mice was significantly higher than that of WT mice(P0.05) and compared with hypoxia groups,the expression of CPT-1 protein of TG mice was higher in hypoxia training groups(P0.05),but hypoxia training didn't change that of WT mice.Conclusion: During hypoxia training,AMPKα2 is activated to regulate the expression level of CPT-1 in skeletal muscle,so that it stimulates fatty acid oxidation." @default.
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- W2354430892 date "2011-01-01" @default.
- W2354430892 modified "2023-09-24" @default.
- W2354430892 title "The Effects of Hypoxia and Hypoxia Training on the Expression of CPT-1 in AMPKα2 Transgenic Mice Skeletal Muscle" @default.
- W2354430892 hasPublicationYear "2011" @default.
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