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- W2354431422 abstract "Objective To prepare Quercetin Nanosuspensions with high drug-loading capacity and small particle size, and study their behaviors in vitro. Methods Quercetin Nanosuspensions were prepared using nano-precipitation and high-pressure homogenization method. The formulation and preparation process were optimized using particle size distribution, drug loading capacity, and stability of samples as evaluating indicators, and then the properties in vitro of optimal sample were studied. Results Ultrasonic injection and high-pressure homogenization was selected as optimal method. The optimal prescription included using TPGS as the stabilizer with the drug-stabilizer ratio of 5:1, DMF as the organic reagent. The optimal preparation was as following: ultrasonic processing was under 10 ℃, the homogenization pressure was 200 MPa, and cycles were 5 times. The prepared Quercetin Nanosuspensions had average diameter(173.21 ± 0.90) nm and Zeta potential(-19.02 ± 0.15) m V. Drug-loading content was calculated to be(80.40±1.44) % and the entrapment efficiency was determined to be(96.41±1.72)%. Quercetin was in the same form of crystalline in Quercetin Nanosuspensions as in the bulk quercetin. Quercetin could release in a sustained release manner during 36 h. Conclusion Using the polymer TPGS, Quercetin Nanosuspensions with high drug-loading and small size sustained released are prepared, and it has obviously in vitro sustained released effect, which dissolves poor water solubility of quercetin, and has good prospect of application." @default.
- W2354431422 created "2016-06-24" @default.
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- W2354431422 date "2015-01-01" @default.
- W2354431422 modified "2023-09-26" @default.
- W2354431422 title "Preparation of Quercetin Nanosuspensions and its properties in vitro" @default.
- W2354431422 hasPublicationYear "2015" @default.
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