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- W2354435230 abstract "Objective To explore the effect of alendronate in the treatment of fibrous dysplasia.Methods From July 2009 to July 2012,23 patients with fibrous dysplasia were selected and given oral alendronate 70mg once a week for maintenance treatment,with continuous use for more than 1 year.Before treatment and after treatment of 6 months and 12 months,the change of pain,X-ray of the lesion and biochemical parameters(ALP) were observed.Results After treatment of 23 cases of fibrous dysplasia,the effect of pain relief was marked in 18 cases,effective in 4 cases,invalid in 1case,and the total efficiency was 95.63%.In 19 patients examined by X-ray,the lesion area of cortical bone thickened,bone mineral density increased and osteolytic area significantly calcificated and deposition and its size did not continue to expand.The lesion area did not change in 2 cases by X-ray examination.One case of lesion had the trend of progressive development,and the total effective rate was 82.64%.The average X-ray radiopacity density of the bone lesion area significantly increased(P0.05).Serum ALP significantly reduced after treatment.Pretreatment serum ALP was(110.25±3.21) U/L;post-treatment serum ALP was(40.35±3.17) U / L(P0.05).Conclusion Bisphosphonate drugs can effectively inhibit bone resorption and promote bone formation,thus they inhibit the fibrous dysplasia progress." @default.
- W2354435230 created "2016-06-24" @default.
- W2354435230 creator A5058412880 @default.
- W2354435230 date "2013-01-01" @default.
- W2354435230 modified "2023-09-27" @default.
- W2354435230 title "Clinical observation of 23 cases with fibrous dysplasia treated by alendronate" @default.
- W2354435230 hasPublicationYear "2013" @default.
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