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- W2354457806 abstract "Objective To explore the effects of piracetam on cerebral edema and change in neurological function induced by cerebral ischemia. Methods The model of cerebral ischemia was established by the unilateral middle cerebral artery occlusion in the rats. The mannitol injection and piracetam injection of different doses were infused into hypoglossal vein respectively in the different group 30 minutes after the middle cerebral artery occlusion. The change in the neurological function, cerebral water content and volume of cerebral infarction were determined 24 hours after cerebral ischemia. Results The disturbance of neurological function and severe cerebral edema were produced by the unilateral middle cerebral artery occlusion in rats. The decreases in the cerebral water content, and volume of cerebral infarction, and improvement in neurological function produced by piracetam injection were dose-dependent in the rats with cerebral ischemia. The decreases in the cerebral water content and volume of the cerebral infarction, and improvement in the neurological function produced by 1 000mg/kg piracetam injection were similar to that produced by 1 000mg/kg mannitol injection. Conclusion The piracetam injection of 750mg/kg or more than 750mg/kg can decrease damage to the brain due to ischemia." @default.
- W2354457806 created "2016-06-24" @default.
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- W2354457806 date "2006-01-01" @default.
- W2354457806 modified "2023-09-27" @default.
- W2354457806 title "Effects of Piracetam on Cerebral Edema and Change in Neurological Function Induced by Cerebral Ischemia in Rats" @default.
- W2354457806 hasPublicationYear "2006" @default.
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